A Dual Setback: <i>Staphylococcus aureus</i> Biofilms From Severe Chronic Rhinosinusitis Show Enhanced Virulence Capacity and Tolerance to Antibiotics
These findings show that whilst severe CRS patients are frequently infected with S. aureus strains that exhibit higher biofilm-mediated virulence, these biofilms are also more difficult to control with standard of care antibiotics. Better personalized therapies are required to manage biofilm-mediated infections in severe CRS patients.
Authors
- Beula Subashini Panchatcharam (ORCID: https://orcid.org/0000-0001-5762-8008)
- Sarah Vreugde (ORCID: https://orcid.org/0000-0003-4719-9785)
- Sima Kianpour Rad (ORCID: https://orcid.org/0000-0001-9951-6936)
- Emma F. Barry (ORCID: https://orcid.org/0000-0003-2742-5650)
- A J Psaltis
- George Bouras (ORCID: https://orcid.org/0000-0002-5885-4186)
- Sholeh Feizi (ORCID: https://orcid.org/0000-0001-5489-4650)
- Clare Cooksley (ORCID: https://orcid.org/0000-0003-3109-4540)
- Cate V. Cheney (ORCID: https://orcid.org/0000-0002-8907-0229)
- Peter‐John Wormald
- Gohar Shaghayegh
Institutions
- Basil Hetzel Institute (AU)
- The University of Adelaide (AU)
Publication Details
- Journal
- International Forum of Allergy & Rhinology
- Published
- 2026-01-06
- DOI
- https://doi.org/10.1002/alr.70092
- Primary Topic
- Sinusitis and nasal conditions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Hospital Research Foundation
- University of Adelaide
- Basil Hetzel Institute for Translational Health Research
- Medical Research Council
- National Health and Medical Research Council