Preferential boosting of SARS-CoV-2 Omicron lineage-specific immune responses by monovalent XBB.1.5 vaccination
Combined, this comprehensive immune profiling demonstrates that despite evidence of imprinted antibody responses targeting ancestral S, monovalent booster vaccination skews the immune response to Omicron lineage recognition.
Authors
- Anna Z. Mykytyn (ORCID: https://orcid.org/0000-0001-7188-6871)
- Lennert Gommers (ORCID: https://orcid.org/0000-0002-4542-0303)
- Daryl Geers (ORCID: https://orcid.org/0000-0002-3432-0761)
- Susanne Bogers (ORCID: https://orcid.org/0000-0002-8212-2946)
- Virgil A. S. H. Dalm (ORCID: https://orcid.org/0000-0001-5945-4435)
- Yvette den Hartog (ORCID: https://orcid.org/0000-0003-4899-3016)
- Rory D. de Vries (ORCID: https://orcid.org/0000-0003-2817-0127)
- Ngoc H. Tan (ORCID: https://orcid.org/0000-0002-8238-951X)
- Melvin Lafeber (ORCID: https://orcid.org/0000-0001-7061-6415)
- Gijsbert P. van Nierop (ORCID: https://orcid.org/0000-0003-1622-8248)
- Douwe F. Postma (ORCID: https://orcid.org/0000-0002-0675-8459)
- Abraham Goorhuis (ORCID: https://orcid.org/0000-0001-7423-6217)
- Roos S. G. Sablerolles (ORCID: https://orcid.org/0000-0002-6647-6584)
- Neeltje A. Kootstra (ORCID: https://orcid.org/0000-0001-9429-7754)
- Muriel Aguilar-Bretones
- Luca M. Zaeck (ORCID: https://orcid.org/0000-0001-7997-493X)
- Menno Cornelis van Zelm
- Kim Handrejk
- Leo G. Visser
- Bart L. Haagmans
- Marion P.G. Koopmans
- Paul A. Gill
- Debbie van Baarle
- Cristina Gonzalez-Lopez
- Corine H. GeurtsvanKessel
- P. Hugo M. van der Kuy
Institutions
- University Medical Center Groningen (NL)
- Leiden University Medical Center (NL)
- Erasmus MC (NL)
- Amsterdam University Medical Centers (NL)
- Monash University (AU)
- University of Amsterdam (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Journal of Infection
- Published
- 2026-01-08
- DOI
- https://doi.org/10.1016/j.jinf.2026.106681
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Moderna
- ZonMw
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- HORIZON EUROPE Framework Programme
- Rijksinstituut voor Volksgezondheid en Milieu