Quantifying structural selection bias in observational cohort data: a ponderation analysis of age - specific incidence rates to inform vaccine safety verification
The HR = 2.714 of the scrutinized study is an unstable statistical artifact. The overwhelming majority of the observed association is a consequence of a fatal design flaw. The HR Corrected of almost 1 confirms that correcting the methodological error eliminates the risk signal, demonstrating a severe lack of internal and external validity of the original study.
Authors
- Marco Roccetti
Institutions
- University of Bologna (IT)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-01-08
- DOI
- https://doi.org/10.3389/fphar.2025.1754809
- Citations
- 1
- Primary Topic
- melanin and skin pigmentation
- Type
- article
- Field-Weighted Citation Impact
- 23.07