Interstitial lung disease in systemic sclerosis—a retrospective cross-sectional study in Taiwan

The SSc-ILD have lower TLC/DLCO, higher CRP, and poorer renal function than the SSc without ILD. Early-onset dyspnea, PH, and renal failure may be independent risk factors for mortality in SSc-ILD. Key Points • 110 SSc (M: F=26:84) were retrospectively analyzed for ILD, with 10.5-47.3% presenting with ILD (UIP the most). • Risk of ILD in SSc = TLC - 0.1 × ESR - 1.5 × CRP can apply in this cohort. • Death originated from infections, PH, and renal failure in addition to early-onset dyspnea in this cohort.