The current state of polygenic scores for the development of lung cancer: a systematic review and validation in UK Biobank
Performance of lung cancer PGS is weak compared to scores for other cancers; the potential benefit of combining genetics with other risk factors for lung cancer remains unclear. Selection of a suitable score is context dependent and requires consideration of the characteristics of the target population (such as ethnicity and tobacco usage).
Authors
- Bayan Galal (ORCID: https://orcid.org/0000-0002-8821-864X)
- Hannah Harrison
- Joe Dennis
- Antonis C. Antoniou
Institutions
- University of Cambridge (GB)
- MRC Epidemiology Unit (GB)
- University of Pennsylvania (US)
Publication Details
- Journal
- British Journal of Cancer
- Published
- 2026-01-08
- DOI
- https://doi.org/10.1038/s41416-025-03330-9
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Oregon Health and Science University
- Cancer Research UK
- National Institute for Health and Care Research
- University College London
- Knight Cancer Institute, Oregon Health and Science University
- NIHR Cambridge Biomedical Research Centre