Association between elevated PRIM1 expression and poor prognosis in human urothelial carcinoma

Our findings advance knowledge regarding the molecular causes of bladder cancer and might facilitate the development of personalized therapies. PRIM1 might serve as a potential therapeutic target for urothelial carcinoma. Therefore, further investigation of how PRIM1 is regulated in this cancer type is essential. This association between PRIM1 and advanced urothelial carcinoma highlights the crosstalk between DNA replication machinery and genetic mutations in bladder cancer, which may open new possibilities for targeted therapies and biomarker discovery.