Integration of single cell and bulk transcriptomic analyses identifies FAM189A2 as a key prognostic gene in lung cancer

Integrating single-cell and bulk transcriptomes links malignant epithelial state programs to prognosis, yields a practical eight-gene risk model validated in multiple LUAD cohorts, and nominates FAM189A2 as a putative tumor suppressor and potential biomarker in lung cancer. These findings suggest testable strategies for risk stratification and therapy selection that warrant prospective evaluation.