Pre‑partum blood leukocyte profiles distinguish gestational inflammatory stages that predict birth‑related adverse outcomes
Combined, longitudinal clinical-inflammatory and personalized data patterns inform whether a pregnancy is associated with double risks and/or when changes occur. Considering pre-partum observations anticipated birth-related outcomes, personalized and prognostic features were demonstrated. Since antenatal care involves routine blood sampling (a low-cost procedure), this methodology is inherently translational. Because construct, internal, external, and statistical validity were supported, if corroborated with prospective studies, this method may assist United Nations' 2023 goals toward reducing infant mortality.
Authors
- Neeta Kumar (ORCID: https://orcid.org/0000-0002-7518-5068)
- Almira L. Hoogesteijn
- Jeanne Marie Fair (ORCID: https://orcid.org/0000-0002-3377-6134)
- Ariel L. Rivas (ORCID: https://orcid.org/0000-0002-2527-6906)
- D. N. Rao (ORCID: https://orcid.org/0000-0003-4598-0623)
- William M. K. Trochim (ORCID: https://orcid.org/0000-0003-0369-2922)
- Michelle Iandiorio
- Hari Shankar (ORCID: https://orcid.org/0000-0002-1736-368X)
- Raja Babu Singh Kushwah
- Yash A. Gupta
Institutions
- Los Alamos National Laboratory (US)
- University of New Mexico (US)
- Cornell University (US)
- Indian Council of Medical Research (IN)
- All India Institute of Medical Sciences (IN)
- Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (MX)
- Penn State Milton S. Hershey Medical Center (US)
- Texas A&M University (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-07
- DOI
- https://doi.org/10.3389/fimmu.2025.1677992
- Citations
- 1
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 24.43
Funders
- Postgraduate Institute of Medical Education and Research, Chandigarh
- Indian Council of Medical Research
- All-India Institute of Medical Sciences