Dysregulated Tfh/B cells and their interactions in neuromyelitis optica spectrum disorder
Circulating Tfh and B cell subsets are dysregulated in AQP4-ab-positive NMOSD, accompanied by increased levels of IL-6, IL-21, and CXCL13. Reciprocal interactions between Tfh and B cells likely contribute to disease pathogenesis.
Authors
- Z. T. Wang
- L Wang
- Jingzi ZhangBao
- Min Wang (ORCID: https://orcid.org/0000-0001-5752-4065)
- Chao Quan (ORCID: https://orcid.org/0000-0003-3388-5215)
- Jiahong Lu
- Hongmei Tan
- Jun Wang
- Wenjuan Huang
- Chuanzhen Lu
- Lei Zhou
- Jian Yu
- Yuxin Fan
- Chongbo Zhao
Institutions
- Shanghai Medical College of Fudan University (CN)
- National Institute of Neurological Disorders and Stroke (US)
- Eye & ENT Hospital of Fudan University (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-06
- DOI
- https://doi.org/10.3389/fimmu.2025.1704282
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China