Immunomodulatory effect of mesenchymal stromal cell overexpressing HLA-G1 in cell-based therapy for myocardial infarction
This study showed that systemic intravenous administration of HLA-G1 overexpressing hUCB-MSCs modulated immune response and increased transplanted hiPSC-CMs' engraftment to improve heart function following AMI.
Authors
- Si-Jia Sun (ORCID: https://orcid.org/0000-0002-2193-7543)
- Wei Zhu (ORCID: https://orcid.org/0000-0003-2312-1174)
- Jie Kong
- Cao Zou
- Ting-Bo Jiang
- Hong-Xia Li
Institutions
- Soochow University (CN)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2026-01-08
- DOI
- https://doi.org/10.1186/s13287-026-04897-7
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 0.00