Transcriptomic insights into early responses of the uterovaginal junction and vagina to avian influenza virus infection in turkey breeder hens

These findings reveal early, tissue-specific molecular vulnerabilities to LPAIV. The UVJ shows disruptions in cellular maintenance and metabolism, potentially impairing fertility, while the vaginal response suggests heightened early immune activation but later compromised barrier integrity. This study offers potential mechanistic insights into LPAIV-induced reproductive pathologies, providing a foundation for targeted strategies to reduce viral impact on flock health and maintain production efficiency.