Analysis of selected cytokines, NLRP3 inflammasome and α-Klotho protein in patients with heart failure after ICD/CRT-D high-voltage intervention
In the peri-shock period, increased IL-6 and IL-10 serum concentrations and changes in 5-diff blood count (increased neutrophils and decreased eosinophils) are observed, which may be associated with a higher risk of ventricular arrhythmia in HF patients. A significant increase in α-Klotho protein concentration, should be taken into account in the development of future diagnostic methods and indicates an important protective role in the inflammatory process.
Authors
- Bruno Hrymniak (ORCID: https://orcid.org/0000-0002-5093-4085)
- Jakub Szyller (ORCID: https://orcid.org/0000-0002-1320-4112)
- Iwona Bil‐Lula (ORCID: https://orcid.org/0000-0002-2769-0166)
- Agnieszka Olejnik (ORCID: https://orcid.org/0009-0002-4180-5270)
- Dariusz Jagielski
- Waldemar Banasiak
- Maciej Zieliński
- Łukasz Kozera
- Mariola Śliwińska-Mossoń
Institutions
- Wrocław University of Science and Technology (PL)
- Military Hospital (PK)
- Wroclaw Medical University (PL)
- Sint Lucas Andreas Hospital (NL)
- Lublin Oncology Center (PL)
- AGH University of Krakow (PL)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2026-01-07
- DOI
- https://doi.org/10.3389/fphys.2025.1721432
- Primary Topic
- Cardiac pacing and defibrillation studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Uniwersytet Medyczny im. Piastów Slaskich we Wroclawiu