Octopamine modulates the innate immune response in Drosophila melanogaster
Our data demonstrate that octopamine exerts a decisive influence on the performance of the Drosophila innate immune system by differentially modulating cellular (phagocytosis) and humoral (AMP expression) immune modules in a receptor‑specific manner. These findings establish octopaminergic signaling through Octβ1R and Octβ2R as an important node of neuro‑immune regulation in invertebrates.
Authors
- Beate Höschler
- Christina Wagner (ORCID: https://orcid.org/0009-0005-8121-0046)
- Stephanie Papenmeier
- Holger Heine
- Karin Uliczka
- Thomas Roeder
Institutions
- Hochschule für Angewandte Wissenschaften Kiel (DE)
- Christian-Albrechts-Universität zu Kiel (DE)
- Research Center Borstel - Leibniz Lung Center (DE)
- German Center for Lung Research (DE)
- Clinical Research Center Kiel (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-08
- DOI
- https://doi.org/10.3389/fimmu.2025.1720126
- Primary Topic
- Invertebrate Immune Response Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Tampereen Yliopisto