NG25 Enhances Anti-Tumor Immunity in KRAS-Mutant Colorectal Cancer
NG25 blocks the NF-κB signaling pathway by targeting TAK1, remodels the immunosuppressive microenvironment of <i>KRAS</i>-mutated colorectal cancer, reduces PD-1 expression and enhances the anti-tumor effect of CD8⁺ T cells. This study provides a theoretical basis for TAK1-targeted therapy and offers a new strategy for immunotherapy of <i>KRAS</i>-mutated colorectal cancer.
Authors
- Yali Tang (ORCID: https://orcid.org/0000-0003-0115-6667)
- Zhigang Mao
- Y Wang
- Qi Xiang
- Jing Zhang (ORCID: https://orcid.org/0000-0002-4530-6754)
- Tang Deng
- Siqi Lan
- Mi Su
- Ma Qizhao
Institutions
- Sichuan University (CN)
- West China Medical Center of Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- OncoTargets and Therapy
- Published
- 2026-01-01
- DOI
- https://doi.org/10.2147/ott.s540070
- Primary Topic
- NF-κB Signaling Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China