Pharmacological S100A8/A9-targeting blockade attenuates toluene diisocyanate-induced mixed granulocytic asthma
Blockade of S100A8/A9 with specific inhibitors effectively suppressed the development of TDI-induced asthma, suggesting that S100A8/A9-targeted therapy holds potential as a clinical intervention for patients with MGA.
Authors
- Lingwei Wang (ORCID: https://orcid.org/0000-0003-2014-117X)
- Rongchang Chen
- Yuanyuan Liu (ORCID: https://orcid.org/0000-0002-7513-1406)
- Yingyun Fu
- Kai Yang
- Shuyu Chen
- Shengguo Liu
- Wei Ma
- Zhou Cai
- Linlin Zheng
- Zhengqiang He
Institutions
- Southern University of Science and Technology (CN)
- Zhujiang Hospital (CN)
- Southern Medical University Shenzhen Hospital (CN)
- Shenzhen Second People's Hospital (CN)
Publication Details
- Journal
- Ecotoxicology and Environmental Safety
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1016/j.ecoenv.2026.119678
- Primary Topic
- S100 Proteins and Annexins
- Type
- article
- Field-Weighted Citation Impact
- 0.00