The role of SP100 in tumour immune microenvironment and prognosis of head and neck squamous cell carcinoma

This study aims to investigate the role and prognostic value of SP100 in the tumour immune microenvironment of HNSCC. A comprehensive bioinformatics analysis was conducted. We first investigated the expression and overall survival (OS) of SP100 in pan-cancers, then, the relationship between tumour immune microenvironment of SP100 in HNSCC was analysed, the SP100-related genes were identified, and finally, a new gene signature was established. SP100 revealed differential expression, correlated with OS in various cancer types, and showed positive associations with immune cell infiltration and immune checkpoints. KEGG analysis showed a focus on 'antigen processing and presentation' and 'natural killer cell-mediated cytotoxicity'. Key SP100-related genes are SP110, MT2A, and CAV1. High SP100 expression negatively correlated with prognosis and positively associated with tumour immune infiltration in HNSCC. Thus, SP100 may be served as a new prognostic biomarker as well as a new target for immune therapy in HNSCC.