From hypereosinophilia to hypereosinophilic syndrome: real-world application of a two-tailed approach for HES diagnosis
HE is a common reason for consultations with allergists and clinical immunologists, and the two-tailed approach, which tests simultaneously for diagnosis and organ damage, should be implemented from the initial evaluation of patients with HE. The lower rate of idiopathic HES diagnosis and the higher frequency of heart involvement we found confirm the usefulness of the tool in reducing the risk of mistakes in classifying HES subtypes and the diagnostic delay, thus allowing prompt and tailored treatment and better outcomes.
Authors
- Richard Borrelli (ORCID: https://orcid.org/0000-0002-2478-1900)
- Eleonora Cerutti
- Monica Fornero
- Luca Lo Sardo (ORCID: https://orcid.org/0009-0004-4201-3456)
- Giulia Anna Maria Luigia Costanzo (ORCID: https://orcid.org/0000-0003-2269-0439)
- Irene Ridolfi
- Giovanni Rolla (ORCID: https://orcid.org/0000-0002-3865-3897)
- Stefania Nicola (ORCID: https://orcid.org/0000-0002-9955-194X)
- Simone Matteo Negrini (ORCID: https://orcid.org/0000-0003-1267-4320)
- Federica Corradi
- Nicolò Rashidy (ORCID: https://orcid.org/0009-0006-4181-0642)
- Luisa Brussino
- Iuliana Badiu (ORCID: https://orcid.org/0000-0001-8364-6023)
- Stefano Del Giacco
Institutions
- University of Cagliari (IT)
- A. O. Ordine Mauriziano di Torino (IT)
- University of Turin (IT)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-06
- DOI
- https://doi.org/10.3389/fimmu.2025.1735131
- Primary Topic
- Eosinophilic Disorders and Syndromes
- Type
- article
- Field-Weighted Citation Impact
- 0.00