Targeting PPP1R15B and ATF4 axis in hepatocellular carcinoma: A novel strategy for overcoming lenvatinib-tolerant persister cells through GPX4-mediated ferroptosis induction
The PPP1R15B-ATF4-GPX4 axis is a key determinant of lenvatinib tolerance in HCC by orchestrating redox adaptation and ferroptosis resistance. Targeting PPP1R15B represents a promising therapeutic strategy to eliminate lenvatinib-tolerant persister cells and overcome acquired resistance in HCC.
Authors
- Kuang-Tai Kuo (ORCID: https://orcid.org/0000-0003-2754-2283)
- Vijesh Kumar Yadav (ORCID: https://orcid.org/0000-0002-2679-1205)
- Yi-Chiao Cheng
- Yih-Giun Cherng
- Shiue-Wei Lai
- Iat-Hang Fong
- Kuen-Haur Lee
- Ming-Yao Chen
Institutions
- Tri-Service General Hospital (TW)
- Taipei Medical University Hospital (TW)
- Taipei Medical University-Shuang Ho Hospital (TW)
- Taipei Medical University (TW)
- National Defense Medical Center (TW)
Publication Details
- Journal
- European Journal of Pharmaceutical Sciences
- Published
- 2026-01-08
- DOI
- https://doi.org/10.1016/j.ejps.2026.107434
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00