Large-scale investigation confirms TRPM3 ion channel dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
The current large-sample-size study confirmed previous results regarding TRPM3 ion channel dysfunction in NK cells in ME/CFS, demonstrating involvement of TRPM3 in the pathomechanism of this condition. Therefore, this multiple-site investigation offers strong evidence demonstrating TRPM3 as a potential biomarker for the diagnosis of ME/CFS, given the accumulating evidence.
Authors
- Etianne Martini Sasso (ORCID: https://orcid.org/0000-0003-1552-5101)
- Livia C. Hool (ORCID: https://orcid.org/0000-0001-7758-5252)
- Katsuhiko Muraki (ORCID: https://orcid.org/0000-0002-4779-6494)
- Natalie Eaton-Fitch (ORCID: https://orcid.org/0000-0002-0815-3162)
- Teagan Er (ORCID: https://orcid.org/0009-0008-3078-4586)
- Sonya Marshall-Gradisnik
Institutions
- Griffith University (AU)
- The University of Western Australia (AU)
- Victor Chang Cardiac Research Institute (AU)
- Aichi Gakuin University (JP)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2026-01-08
- DOI
- https://doi.org/10.3389/fmed.2025.1703924
- Primary Topic
- Ion Channels and Receptors
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Victor Chang Cardiac Research Institute
- Medical Research Council
- National Health and Medical Research Council