Bridging the gap with amide linkers: rational design, synthesis, and multi-target evaluation of sulfonamide/acetamide-NSAID hybrids as dual COX-2/5-LOX inhibitors
The new hybrids exhibit strong COX-2/5-LOX inhibition, suggesting their structural framework is crucial for developing safer anti-inflammatory drugs.
Authors
- Asmaa Samir Elzaitony
- Mona M. Kamal (ORCID: https://orcid.org/0000-0002-5986-5012)
- Mohammad M. Al‐Sanea (ORCID: https://orcid.org/0000-0002-9820-4022)
- Shaimaa Hussein (ORCID: https://orcid.org/0000-0003-0998-482X)
- Triveena M. Ramsis (ORCID: https://orcid.org/0000-0003-2485-5479)
- Yousry A. Ammar (ORCID: https://orcid.org/0000-0001-8989-4394)
- Omaima Ali (ORCID: https://orcid.org/0000-0002-1015-1035)
- E M M Fayed
- Arafa Musa
- Ahmed Ragab
- Moustafa S. Abusaif
Institutions
- Sinai University (EG)
- Jouf University (SA)
- Slovak Academy of Sciences (SK)
- University of Florida (US)
- Al-Azhar University (ID)
- Egyptian Government (EG)
- Galala University
- Florida College (US)
Publication Details
- Journal
- Future Medicinal Chemistry
- Published
- 2026-01-06
- DOI
- https://doi.org/10.1080/17568919.2025.2605716
- Citations
- 1
- Primary Topic
- Inflammatory mediators and NSAID effects
- Type
- article
- Field-Weighted Citation Impact
- 32.57