Metformin and CoQ10 combination therapy: a novel approach to mitigating ischemia-reperfusion injury and cognitive impairment

Co-administration of MT and CQ offered enhanced neuroprotection compared to individual treatments. This benefit may stem from additive or synergistic antioxidant effects and AMPK activation, suggesting potential for combined therapy in ischemic stroke management.

Authors

Chandrashekhar Upasani (ORCID: https://orcid.org/0000-0003-4446-1557)
Vipin Dhote (ORCID: https://orcid.org/0000-0003-3880-5616)
Aman B. Upaganlawar (ORCID: https://orcid.org/0000-0003-4122-5081)
Avinash Singh Mandloi
Vivek Kumar Sinha

Institutions

SCMS Group of Educational Institutions (IN)
Savitribai Phule Pune University (IN)

Publication Details

Journal: Brain Injury
Published: 2026-01-06
DOI: https://doi.org/10.1080/02699052.2025.2612032
Primary Topic: Coenzyme Q10 studies and effects
Type: article
Field-Weighted Citation Impact: 0.00

Controls

|||

ALL TIME

JAN

FEB

MAR

APR

MAY

JUN

JUL

AUG

SEP

OCT

article

Metformin and CoQ10 combination therapy: a novel approach to mitigating ischemia-reperfusion injury and cognitive impairment

Chandrashekhar Upasani, Vipin Dhote, Aman B. Upaganlawar, Avinash Singh Mandloi et al.

Jan 6, 2026

Brain Injury

Coenzyme Q10 studies and effects

article

Metformin and CoQ10 combination therapy: a novel approach to mitigating ischemia-reperfusion injury and cognitive impairment

Chandrashekhar Upasani, Vipin Dhote, Aman B. Upaganlawar, Avinash Singh Mandloi, Vivek Kumar Sinha

January 6, 2026article en

Abstract

Co-administration of MT and CQ offered enhanced neuroprotection compared to individual treatments. This benefit may stem from additive or synergistic antioxidant effects and AMPK activation, suggesting potential for combined therapy in ischemic stroke management.

Brain InjuryVol. 40(4)

SCMS Group of Educational Institutions (IN), Savitribai Phule Pune University (IN)

Good health and well-being

Openalex Percentile: Top 95%

Coenzyme Q10 studies and effects

DOI Source OpenAlex

AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.