Identification of novel germline and somatic mutations associated with hepatocellular carcinoma by next-generation sequencing
This study offers the first comprehensive overview of novel germline and somatic mutations in Tunisian HCC patients, representing a North African cohort, and highlights key molecular drivers of hepatocarcinogenesis. These findings support the integration of genetic profiling into clinical practice to enhance early diagnosis and guide personalized therapies.
Authors
- N. Arfa
- Ahmed Baligh Laaribi (ORCID: https://orcid.org/0000-0002-6515-1737)
- Riadh Sassi
- B. Bouchabou
- Wafa Babay
- Dhouha Bacha (ORCID: https://orcid.org/0000-0002-8430-0072)
- Sana Ben Slama (ORCID: https://orcid.org/0000-0001-8897-398X)
- R Ennaifer
- A. Lahmar
- Abdelmalek Lekired (ORCID: https://orcid.org/0000-0001-7276-3785)
- S. Omrani
- Nadia Boujelbène (ORCID: https://orcid.org/0000-0002-4888-8198)
- Asma Mehri (ORCID: https://orcid.org/0009-0005-3797-0320)
- Rached Bayar
- Hadda-Imene Ouzari
Institutions
- Tunis University (TN)
- Hôpital Mongi Slim (TN)
- Tunis El Manar University (TN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-01-06
- DOI
- https://doi.org/10.3389/fphar.2025.1699280
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00