Impact of Evolving Evidence on Pharmacological Therapy for Alcohol‐Associated Hepatitis in Alberta: A Population‐Based Study of Practice Trends and <scp>MELD</scp> ‐Stratified Effectiveness of Corticosteroids

RCT evidence led to a rapid reversal in PTX prescribing prior to formal guideline updates. Real-world data support a modest short-term benefit of CS and illustrate the potential of target trial emulation to assess treatment effectiveness in specific groups of patients.

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Publication Details

Journal
Alimentary Pharmacology & Therapeutics
Published
2026-01-07
DOI
https://doi.org/10.1111/apt.70517
Primary Topic
Alcohol Consumption and Health Effects
Type
article
Field-Weighted Citation Impact
0.00

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article

Impact of Evolving Evidence on Pharmacological Therapy for Alcohol‐Associated Hepatitis in Alberta: A Population‐Based Study of Practice Trends and MELD ‐Stratified Effectiveness of Corticosteroids

J. G. Abraldes, Abdel‐Aziz Shaheen, Bryce Tkachuk, Meng Wang
Alimentary Pharmacology & Therapeutics
Alcohol Consumption and Health Effects
article

Impact of Evolving Evidence on Pharmacological Therapy for Alcohol‐Associated Hepatitis in Alberta: A Population‐Based Study of Practice Trends and MELD ‐Stratified Effectiveness of Corticosteroids

J. G. Abraldes, Abdel‐Aziz Shaheen, Bryce Tkachuk, Meng Wang
article en

Abstract

RCT evidence led to a rapid reversal in PTX prescribing prior to formal guideline updates. Real-world data support a modest short-term benefit of CS and illustrate the potential of target trial emulation to assess treatment effectiveness in specific groups of patients.

Alimentary Pharmacology & Therapeutics
Alberta Health Services (CA), University of Alberta (CA), University of Calgary (CA)
Canadian Institutes of Health Research
Good health and well-being
Openalex Percentile: Top 96%
Alcohol Consumption and Health Effects
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