Genomic and transcriptomic analyses of melanoma in Japanese patients reveal candidate biomarkers for immune checkpoint inhibitor responders
To our knowledge, this is the first and largest genomic cohort study in Japanese patients with melanoma in which tumor samples were prospectively analyzed. Genomic and transcriptomic analyses reveal candidate biomarkers for ICI in Japan.
Authors
- Jun Asai (ORCID: https://orcid.org/0000-0002-7610-0820)
- Yukiko Kiniwa (ORCID: https://orcid.org/0000-0003-3757-7375)
- Kazuma Kiyotani (ORCID: https://orcid.org/0000-0002-9236-9061)
- Kohtarou Nagase
- Ryuhei Okuyama (ORCID: https://orcid.org/0000-0003-4360-6865)
- Takehiro Noda (ORCID: https://orcid.org/0000-0002-6768-5783)
- Atsushi Tanemura (ORCID: https://orcid.org/0000-0002-5239-8474)
- Noritaka Tanaka (ORCID: https://orcid.org/0000-0002-6495-540X)
- Takashi Fujimura (ORCID: https://orcid.org/0000-0001-7442-5974)
- Kayo Kunimoto (ORCID: https://orcid.org/0000-0001-8102-1193)
- Hiroshi Yamano- Uchi
- Koji Yoshino
- Yoshihiro Komohara
- Shin Yamazaki (ORCID: https://orcid.org/0000-0002-2309-2425)
- A. Kobayashi
- S. Fukushima
- S. Mori
- T. Maekawa
- H. Kato
- T. Ito
- S. Matsushita
- T. Kimura
- Y. Fujisawa
- H. Yano
Institutions
- Kyushu University (JP)
- Shinshu University (JP)
- University of Tsukuba (JP)
- Jichi Medical University (JP)
- Kumamoto Health Science University (JP)
- Saga University (JP)
- Wakayama Medical University (JP)
- Tohoku University (JP)
- Tokyo Metropolitan Komagome Hospital (JP)
- Nagoya City University (JP)
- Kyoto Prefectural University of Medicine (JP)
- National Institute of Biomedical Innovation, Health and Nutrition (JP)
- National Hospital Organization Kyushu Cancer Center (JP)
- The Cancer Institute Hospital (JP)
- Kagoshima Medical Center (JP)
- Japanese Foundation For Cancer Research (JP)
- Osaka Metropolitan University (JP)
- Nagoya University (JP)
- Tokyo Metropolitan University (JP)
- Kumamoto University (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Communications Medicine
- Published
- 2026-01-07
- DOI
- https://doi.org/10.1038/s43856-025-01341-4
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Clinical Trial Center, China Medical University Hospital