Genomic and transcriptomic analyses of melanoma in Japanese patients reveal candidate biomarkers for immune checkpoint inhibitor responders

To our knowledge, this is the first and largest genomic cohort study in Japanese patients with melanoma in which tumor samples were prospectively analyzed. Genomic and transcriptomic analyses reveal candidate biomarkers for ICI in Japan.

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Publication Details

Journal
Communications Medicine
Published
2026-01-07
DOI
https://doi.org/10.1038/s43856-025-01341-4
Primary Topic
Cancer Immunotherapy and Biomarkers
Type
article
Field-Weighted Citation Impact
0.00

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Genomic and transcriptomic analyses of melanoma in Japanese patients reveal candidate biomarkers for immune checkpoint inhibitor responders

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Communications Medicine
Cancer Immunotherapy and Biomarkers
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Genomic and transcriptomic analyses of melanoma in Japanese patients reveal candidate biomarkers for immune checkpoint inhibitor responders

Jun Asai, Yukiko Kiniwa, Kazuma Kiyotani, Kohtarou Nagase, Ryuhei Okuyama, Takehiro Noda, Atsushi Tanemura, Noritaka Tanaka, Takashi Fujimura, Kayo Kunimoto, Hiroshi Yamano- Uchi, Koji Yoshino, Yoshihiro Komohara, Shin Yamazaki, A. Kobayashi, S. Fukushima, S. Mori, T. Maekawa, H. Kato, T. Ito, S. Matsushita, T. Kimura, Y. Fujisawa, H. Yano
article en

Abstract

To our knowledge, this is the first and largest genomic cohort study in Japanese patients with melanoma in which tumor samples were prospectively analyzed. Genomic and transcriptomic analyses reveal candidate biomarkers for ICI in Japan.

Communications MedicineVol. 6(1)
Kyushu University (JP), Shinshu University (JP), University of Tsukuba (JP), Jichi Medical University (JP), Kumamoto Health Science University (JP), Saga University (JP), Wakayama Medical University (JP), Tohoku University (JP), Tokyo Metropolitan Komagome Hospital (JP), Nagoya City University (JP), Kyoto Prefectural University of Medicine (JP), National Institute of Biomedical Innovation, Health and Nutrition (JP), National Hospital Organization Kyushu Cancer Center (JP), The Cancer Institute Hospital (JP), Kagoshima Medical Center (JP), Japanese Foundation For Cancer Research (JP), Osaka Metropolitan University (JP), Nagoya University (JP), Tokyo Metropolitan University (JP), Kumamoto University (JP), The University of Osaka (JP)
Clinical Trial Center, China Medical University Hospital
Good health and well-being
Openalex Percentile: Top 96%
Cancer Immunotherapy and Biomarkers
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