Cardiac substructure-guided radiotherapy planning for esophageal cancer: a novel strategy for cardiotoxicity reduction

The research shows that the novel method for protecting sensitive cardiac substructures can effectively reduce the dose of cardiac substructures without significantly increasing the dose of other organs at risk (OARs). By delineating sensitive cardiac substructures, it could significantly decrease the NTCP of the heart while increasing TCP of the target, thereby improving the quality of clinical plans.