Gallbladder disease and colorectal cancer: a two-sample bidirectional Mendelian randomization study

This two-sample, bidirectional MR study found no evidence for a causal relationship in either direction between gallbladder disease and CRC, suggesting that gallbladder disease and its genetic susceptibility are unlikely to be major genetic drivers of colorectal carcinogenesis. Individuals should not be classified as high-risk for CRC solely on the basis of gallbladder disease or cholecystectomy history, although coexisting metabolic risk factors still warrant comprehensive management and further study.