NOP56 interacts with Fibrarin to regulate the PI3K/AKT signaling pathway and inhibit apoptosis of hepatocellular carcinoma
NOP56 promotes HCC progression through the NOP56-FBL-PI3K/AKT/CREB axis. These findings reveal a previously unrecognized oncogenic role of nucleolar proteins in HCC and highlight this signaling axis as a promising therapeutic target.
Authors
- H. Chen
- Xinggang Fan (ORCID: https://orcid.org/0000-0001-9475-429X)
- Di Cui
Institutions
- Fuyang Normal University (CN)
- Fuyang Second People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2026-01-06
- DOI
- https://doi.org/10.3389/fonc.2025.1728226
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fuyang Normal University