Scalable mechanochemical synthesis of amides using bead milling technology
A scalable protocol for mechanochemical amide bond formation was developed using a commercially available agitator bead mill without requiring reagent excess, added base or large quantities of organic solvent, significantly reducing waste generation.
Authors
- Sándor B. Ötvös (ORCID: https://orcid.org/0000-0001-6673-1744)
- Pietro Caboni (ORCID: https://orcid.org/0000-0002-7507-4974)
- Andrea Porcheddu
- C. Oliver Kappe
Institutions
- University of Graz (AT)
- University of Cagliari (IT)
- Nawi Graz (AT)
- Research Center Pharmaceutical Engineering (Austria) (AT)
Publication Details
- Journal
- Green Chemistry
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1039/d5gc04764a
- Citations
- 1
- Primary Topic
- Crystallography and molecular interactions
- Type
- article
- Field-Weighted Citation Impact
- 26.05