Atypical case of intracerebral schwannoma in a child

A 2-year-old girl presented with headache following a fall at home.Magnetic Resonance Imaging revealed a well-circumscribed, slightly lobulated mass in the left frontal lobe adjacent to the body of the left lateral ventricle, that showed contrast enhancement with surrounding edema.Peripheral fissures (arrows in Fig. 1A) containing fluid were observed within the mass-an imaging feature rarely seen in other intracranial tumors.The patient subsequently underwent neuronavigation-assisted surgical resection.Histopathological examination demonstrated spindle-shaped tumor cells.Immunohistochemistry revealed the following profile: cytokeratin (-), vimentin (+), S-100 protein (+), SOX-10 (+), epithelial membrane antigen (-), progesterone receptor (focal+), cluster of differentiation 34 (vascular+), Kiel-67 antigen (5 % +), tumor protein p53 (wildtype +), glial fibrillary acidic protein (focal weak+), oligodendrocyte transcription factor 2 (-), and isocitrate dehydrogenase 1 (-).These findings supported a diagnosis of schwannoma.No progression was observed at the 6-month follow-up.Schwannomas are relatively common benign peripheral nerve tumors; however, they are uncommon in children and extremely rare when located intracerebrally. 1 This rarity may be due to the active myelination process during childhood. 2