Diffusion kurtosis imaging detects cortical microstructural alterations in amyloid-positive MCI patients
Elevated MK in Aβ-positive MCI patients suggests that DKI can detect early microstructural changes associated with the presence of amyloid pathology before the onset of cortical atrophy. MK may serve as a promising non-invasive biomarker for identifying prodromal AD and monitoring disease progression.
Authors
- Rune B. Nielsen
- Hanne Gottrup (ORCID: https://orcid.org/0000-0003-2681-6174)
- David J. Brooks (ORCID: https://orcid.org/0000-0003-2602-2518)
- Simon Fristed Eskildsen (ORCID: https://orcid.org/0000-0003-4242-9158)
- Peter Parbo (ORCID: https://orcid.org/0000-0002-5792-1607)
- Rola Ismail (ORCID: https://orcid.org/0000-0003-0837-6603)
- Rikke Beese Dalby (ORCID: https://orcid.org/0000-0002-3385-1480)
- Anna Tietze (ORCID: https://orcid.org/0000-0002-2601-9055)
- Hans Brændgaard
- Leif Østergaard
Institutions
- Aarhus University (DK)
- Odense University Hospital (DK)
- Aarhus University Hospital (DK)
- Humboldt-Universität zu Berlin (DE)
- Vejle Sygehus (DK)
- Hospital South West Jutland (DK)
- Freie Universität Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
- Newcastle University (GB)
Publication Details
- Journal
- Frontiers in Dementia
- Published
- 2026-01-06
- DOI
- https://doi.org/10.3389/frdem.2025.1725754
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Arcadia Fund
- Lundbeckfonden
- H. Lundbeck A/S
- Strategic Research Council