Evaluating Photochemical Interactions Between Rose Bengal Photodynamic Antimicrobial Therapy and Topical Antifungals in Fungal Keratitis Isolates
Across both Fusarium and Aspergillus isolates, treatment responses to antifungals with or without RB-PDAT demonstrated strain-specific effects. The increased fungal inhibition and maintained stability of voriconazole when combined with RB-PDAT highlight its potential compatibility with RB-PDAT. In contrast, the reduced inhibition and degradation of natamycin and amphotericin B with RB-PDAT suggests that drug stability may be a factor to consider when integrating RB-PDAT into fungal keratitis management.
Authors
- Abia Ahmed (ORCID: https://orcid.org/0000-0002-4760-7438)
- Roger M. Leblanc (ORCID: https://orcid.org/0000-0001-8836-8042)
- Lisa Gonzalez (ORCID: https://orcid.org/0000-0002-2800-1414)
- Felipe Echeverri Tribin (ORCID: https://orcid.org/0009-0004-0408-697X)
- Suraj Paudyal
- Guillermo Amescua (ORCID: https://orcid.org/0000-0003-2854-0626)
- Alejandro Arboleda (ORCID: https://orcid.org/0000-0002-5060-1782)
- Heather A. Durkee (ORCID: https://orcid.org/0000-0002-5476-5813)
- Mariela C Aguilar (ORCID: https://orcid.org/0000-0003-1891-7813)
- Brandon Chou (ORCID: https://orcid.org/0009-0000-5025-2976)
- D. C. Miller
- J. M. M. Parel
- Katherine Krishna
- Braulio C. L. B. Ferreira
- James Lai
- Harry W. Flynn
Institutions
- University of Miami (US)
- Baylor College of Medicine (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2026-01-07
- DOI
- https://doi.org/10.1167/iovs.67.1.11
- Primary Topic
- Ocular Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Research to Prevent Blindness
- University of Miami
- Henri and Flore Lesieur Foundation
- National Institutes of Health