Insights into the pro-angiogenic effect of hydroxysafflor yellow A (HSYA): targeting HIF-1α and MMP9 in HMEC-1
HSYA demonstrates significant pro-angiogenic activity on HMEC-1. Mechanistically, HSYA modulates multiple signaling pathways, with HIF-lα and MMP9 demonstrating regulatory significance. These findings suggest a molecular basis for HSYA's therapeutic potential in ischemic vascular pathologies.
Authors
- H X Wang
- Fan Lin (ORCID: https://orcid.org/0009-0003-2210-6279)
- Zengxi Yao
- Jiaming Yu
- Juanli Fu
- Yingmei Dong
- Yizheng Wang
Institutions
- Fujian University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Chemistry
- Published
- 2026-01-06
- DOI
- https://doi.org/10.3389/fchem.2025.1713765
- Primary Topic
- Sunflower and Safflower Cultivation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Fujian Province