Tuft cell cysteinyl leukotrienes are necessary for rhinovirus-induced mucus metaplasia, type 2 inflammation and airway hyperresponsiveness in immature mice
Tuft cell-derived cysLTs are required for mucous metaplasia, type 2 inflammation and airways hyperresponsiveness in immature mice exposed to heterologous viral infection.
Authors
- S. Singh
- Hedieh Briggs
- Marc B. Hershenson (ORCID: https://orcid.org/0000-0001-9436-5593)
- De’Jana Parker
- Heidi R. Flori (ORCID: https://orcid.org/0000-0002-6047-6970)
- Jing Lei (ORCID: https://orcid.org/0000-0003-3104-9387)
- Yiran Li (ORCID: https://orcid.org/0000-0002-4658-3876)
- Derek Flores
- Baljeet Domala
- J. Kelley Bentley
- M. Claire Reiner
- Alex L. Sliwicki
Institutions
- University of Michigan (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-07
- DOI
- https://doi.org/10.3389/fimmu.2025.1709008
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute of General Medical Sciences