CGR11 promotes hepatocellular carcinoma progression by regulating autophagy through the PI3K/AKT pathway
Our findings establish CGR11 as a novel oncogenic regulator that contributes to HCC progression by suppressing autophagy via PI3K/AKT activation. Targeting the CGR11-PI3K/AKT axis may therefore provide a promising avenue for precision therapeutic intervention in HCC.
Authors
- C F Peng
- Yinghui Song (ORCID: https://orcid.org/0000-0002-1728-9109)
- Jiayi Liu (ORCID: https://orcid.org/0000-0003-1819-2998)
- Xiaoxia Han
- Junjie Liu (ORCID: https://orcid.org/0000-0002-8409-4766)
- Yang Xing
- Xinrun Wang (ORCID: https://orcid.org/0009-0000-6761-0506)
- Zhiguo Tan
- Yufang Leng
- Jia Zhou
- Sulai Liu
- Bo Sun
Institutions
- Hunan Normal University (CN)
- Hunan Mawangdui Hospital (CN)
- Hunan Provincial People's Hospital (CN)
- First Hospital of Lanzhou University (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2026-01-07
- DOI
- https://doi.org/10.3389/fcell.2025.1692480
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Lanzhou University
- National Natural Science Foundation of China