Heterogeneity in tau onset, patterns and accumulation rates are explained by age of amyloid onset
Earlier amyloid onset predicts earlier tau onset and faster more neocortically pronounced tau accumulation. At the same time, younger amyloid onset is linked to a longer delay to tauopathy compared to individuals with older-age amyloid onset. A longer delay between amyloidosis and tauopathy in patients with earlier onset of amyloidosis may widen the window of opportunity for anti-amyloid drugs to prevent more aggressive tauopathy in these at risk individuals.
Authors
- Amir Dehsarvi (ORCID: https://orcid.org/0000-0001-7116-9741)
- Anna Steward (ORCID: https://orcid.org/0000-0002-8438-3760)
- Fabian Hirsch (ORCID: https://orcid.org/0000-0002-5370-4031)
- Michael Schöll (ORCID: https://orcid.org/0000-0001-7800-1781)
- Nicolai Franzmeier (ORCID: https://orcid.org/0000-0001-9736-2283)
- Davina Biel (ORCID: https://orcid.org/0000-0002-2597-1992)
- for the Alzheimer’s Disease Neuroimaging Initiative
- Sebastian N. Roemer‐Cassiano
- Zeyu Zhu
- Anna Dewenter
- Lukas Frontzkowski
- Matthias Brendel
- Günter U Höglinger
Institutions
- LMU Klinikum (DE)
- Munich Cluster for Systems Neurology (DE)
- UK Dementia Research Institute (GB)
- Max Planck Institute for Human Cognitive and Brain Sciences (DE)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
- Ludwig-Maximilians-Universität München (DE)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_104868
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00