The Efficacy of Phytoestrogens and L- Carnitine as an Adjuvant to Clomiphene Citrate in Ovulation Induction in Women with Polycystic Ovarian Syndrome.

Background: Many plants and fungi contain phytoestrogens, which are natural compounds that exhibit estrogenic activity. Aim: To examine the effectiveness of adding oral Phytoestrogens and L-carnitine to clomiphene citrate (CC) in improving the ovulation process and the pregnancy rate. Methods: This prospective randomized clinical research was performed on 300 patients aged from 20 to 35 years old, with polycystic ovarian syndrome, infertile patients, and an infertility duration of less than 10 years. cases were separated into three equal groups: Group A: received only CC 100 mg/d divided into two doses for 5 days from day 2 of the cycle with timed intercourse. Group B: received CC 100 mg/d divided into two doses for 5 days, plus oral L-Carnitine 3000 mg divided into three doses daily for ten days, and both started from day two of the cycle with timed intercourse. Group C: received CC 100 mg/d divided into two doses for 5 days, plus oral L-Carnitine 3000 mg divided into three doses daily, and C. racimosa 120mg divided into 3 doses for 10 days, and all started from day 2 of the cycle with timed intercourse. Results: The number of preovulatory follicles over seventeen millimeters varied significantly among the groups. Endometrial thickness variations among the groups were statistically significant. Conclusions: There is a trend of increasing pregnancy rates from Group A to Group C.