Controlled Human Infection of Healthy Adults With Lyophilized <i>Neisseria lactamica</i> Induces Asymptomatic, Immunogenic Nasopharyngeal Carriage in the United Kingdom and Mali
Intranasal inoculation with LyoNlac was safe and induced immunogenic nasopharyngeal colonization in healthy adults in the United Kingdom and Mali. Future clinical trials to determine whether LyoNlac reduces meningococcal carriage and transmission in the meningitis belt are warranted.
Authors
- Jonathan M Guy (ORCID: https://orcid.org/0000-0001-9176-6092)
- Fatoumata Diallo (ORCID: https://orcid.org/0000-0002-1423-3417)
- Eleanor F Jones
- A Traore (ORCID: https://orcid.org/0000-0001-6814-3305)
- Henry Badji (ORCID: https://orcid.org/0000-0003-3681-5976)
- Youssouf Traoré (ORCID: https://orcid.org/0009-0003-4350-9843)
- Fadima Cheick Haidara (ORCID: https://orcid.org/0000-0003-1121-2941)
- Muktar Ibrahim (ORCID: https://orcid.org/0000-0002-2027-3095)
- Carl N. Webb (ORCID: https://orcid.org/0000-0001-6401-4397)
- Jenny MacLennan
- M D Tapia
- R C Read
- U Onwuchekwa
- A P Dale
- R S Heyderman
- A A Theodosiou
- A R Gorringe
- S O Sow
- D F Gbesemete
- J R Laver
- S N Faust
Institutions
- University of Maryland, Baltimore (US)
- University of Oxford (GB)
- Centre Pour le Développement des Vaccins-Mali (ML)
- NIHR Southampton Biomedical Research Centre (GB)
- Institute of Infection and Immunity (CA)
- University of Southampton (GB)
- University College London (GB)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2025-12-26
- DOI
- https://doi.org/10.1093/ofid/ofaf809
- Primary Topic
- Bacterial Infections and Vaccines
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Pfizer
- AstraZeneca
- GlaxoSmithKline
- Sanofi
- University Hospital Southampton NHS Foundation Trust
- Novavax
- National Institute for Health and Care Research
- Seqirus