Identification and Validation of Key Purine Metabolism-Related Genes in Ulcerative Colitis Using Bioinformatics and Machine Learning
PDE4B is a good biomarker related to purine metabolism in UC. Inhibiting PDE4B expression helps alleviate UC symptoms, providing a new approach to the pathogenesis and treatment of UC.
Authors
- Yifang Zhang (ORCID: https://orcid.org/0000-0003-3762-3589)
- Wenjing Xue
- Shengkai Zhang (ORCID: https://orcid.org/0000-0003-0154-4897)
- Wei Hu (ORCID: https://orcid.org/0000-0001-9332-9670)
- Dongwei Du (ORCID: https://orcid.org/0000-0003-0050-3487)
- Q Wang
- Lan Yi
- Xiang Wen
- Su Zhang
- Yanling Zeng
Institutions
- Fujian Medical University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
- Second Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2026-01-01
- DOI
- https://doi.org/10.2147/jir.s557806
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Fujian Province
- Fujian Medical University