Significance of diffusing capacity of the lungs for carbon monoxide on chronic thromboembolic pulmonary hypertension
Reduced diffusing capacity of the lungs for carbon monoxide (DLco) reflects microvasculopathy in chronic thromboembolic pulmonary hypertension, yet its clinical value is uncertain. In a Japanese nationwide registry (2018-2023) we studied 1270 patients: 486 formed an event cohort and 299 a treatment cohort who underwent pulmonary endarterectomy or balloon pulmonary angioplasty. Lower baseline DLco was indicative of smaller postprocedural improvements in mean pulmonary artery pressure, pulmonary vascular resistance and cardiac index (all p≤0.023) and a higher risk of clinical events (HR 0.971, p=0.005). Outcomes deteriorated below 59.6%, indicating DLco may help stratify prognosis and treatment benefit.
Authors
- Ayako Shigeta (ORCID: https://orcid.org/0000-0002-4536-4487)
- Hidekazu Ikemiyagi
- Kouta Funakoshi (ORCID: https://orcid.org/0000-0001-7015-4353)
- Kayoko Kubota (ORCID: https://orcid.org/0000-0003-3632-7286)
- Koshin Horimoto (ORCID: https://orcid.org/0000-0002-8625-2211)
- Ichizo Tsujino
- Shiro Adachi (ORCID: https://orcid.org/0000-0001-8924-1916)
- Yoshihiro Dohi (ORCID: https://orcid.org/0000-0002-4240-2097)
- Y. Fukumoto
- Nobutaka Ikeda (ORCID: https://orcid.org/0000-0002-1615-3736)
- Takashi Kawakami (ORCID: https://orcid.org/0000-0002-2841-4198)
- Nobuhiro Tanabe
- Koichiro Tatsumi
- Nobuhiro Yaoita
- Yoshito Ogihara
- Yuichi Tamura
- Takahiro Hiraide
- Takumi Inami
- Shun Minatsuki
- Hitoshi Ogino
- Masaru Hatano
- Hiroto Shimokawahara
- Jun Yamashita
- Yu Taniguchi
- Kazuya Hosokawa
- Kohtaro Abe
Institutions
- Kurume University (JP)
- Kagoshima University (JP)
- SHOWA Medical University (JP)
- Toho University (JP)
- Kyushu University (JP)
- Tokyo Medical University (JP)
- Chiba University (JP)
- Mie University (JP)
- Kyorin University (JP)
- Keio University (JP)
- Hokkaido University (JP)
- University of the Ryukyus (JP)
- Chibaken Saiseikai Narashino Hospital (JP)
- Toho University Ohashi Medical Center (JP)
- Tohoku University Hospital (JP)
- Kyushu University Hospital (JP)
- Matsuyama Red Cross Hospital (JP)
- Kure Kyosai Hospital (JP)
- National Hospital Organization (JP)
- Okayama Medical Center (JP)
- Mita Hospital (JP)
- Nagoya University (JP)
- Kobe University (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- Thorax
- Published
- 2026-01-07
- DOI
- https://doi.org/10.1136/thorax-2025-223670
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00