Baseline multi‐omics signatures could predict therapeutic response to neoadjuvant anti‐PD‐1 immunochemotherapy in non‐small‐cell lung cancer
Baseline metagenomic and metabolomic signatures were significantly associated with the major pathologic response of neoadjuvant anti-PD-1 immunochemotherapy. Integrated microbial model (consists of Clostridium sp. M62/1 and Eisenbergiella tayi) and metabolomic model (consists of linoleic acid, oxindole-3-acetic acid and quinolinic acid) could provide early predictions of the response.
Authors
- Wenyu Zhai
- H. Long
- Shaoxing Guan (ORCID: https://orcid.org/0000-0003-1881-9543)
- Yuheng Zhou (ORCID: https://orcid.org/0000-0003-3118-604X)
- Ailing Cao
- Yaobin Lin
- Yanping Guan
- Shoucheng Feng
- Xueding Wang
- Youhao Chen
- Yiyu Zhang
- Min Huang
Institutions
- Sun Yat-sen University (CN)
- Sun Yat-sen University Cancer Center (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1002/ctm2.70579
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- Higher Education Discipline Innovation Project
- National Health Commission of the People's Republic of China
- National Key Research and Development Program of China