Ulcerative colitis model triggers gut α-Synuclein aggregation without brain involvement or neuronal loss in female rats
These results underscore the critical importance of considering sex differences in experimental PD models and in clinical practice, as such differences may significantly influence PD pathogenesis.
Authors
- María Angustias Roca-Ceballos
- Rocío Espada Ruíz
- Manuel Sarmiento Soto (ORCID: https://orcid.org/0000-0003-0997-0153)
- José Luis Venero
- Rocío M. de Pablos
- María José Peral
- Antonio J. Herrera
- Ana María Espinosa-Oliva
- Pablo García-Miranda
- María Dolores Vázquez-Carretero
Institutions
- Instituto de Biomedicina de Sevilla (ES)
- Hospital Universitario Virgen del Rocío (ES)
- Universidad de Sevilla (ES)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-06
- DOI
- https://doi.org/10.3389/fimmu.2025.1637548
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00