Synthesis and study of antioxidant and antimicrobial activityof imidazole derivatives

In the current research, imidazole derivatives are synthesized via a new process via four component reactions of trichloroacetonitrile, amides, alkyl bromides and amino acids catalyzed by zinc oxide nanoparticles (ZnO-NPs) as a simple and recyclable catalyst in water at room temperature. Also, the antioxidation property of some prepared imidazole is investigated by employing trapping diphenyl-picrylhydrazine (DPPH) radical and the ferric reduction experiment. Among the investigated compounds, compounds 5b exhibits good results with butylated hydroxytoluene (BHT) and 2-tert-butylhydroquinone (TBHQ) as standard antioxidants. In addition, the Gram positive and negative bacteria disk diffusion research is used for the confirmation of antimicrobial power of some prepared imidazoles. The achieved outcomes of disk diffusion experiment showed that these compounds resisted the growth of bacteria. Our procedure has a few benefits relative to the reported method such as good rate of reaction, high efficiency, simple removal of catalyst from mixture of reaction. In the yield of the product, ZnO-NPs show a satisfactory recyclable activity.