Primary Large Cell Neuroendocrine Carcinoma of the Prostate Gland: An Uncommon Case

Abstract Primary large cell neuroendocrine prostate cancer is a rare and aggressive cancer commonly observed as a transformation of an already known prostate adenocarcinoma and on long-term androgen deprivation, although it can arise de novo. It has high potential for distant metastatic spread and is generally associated with poor survival compared to the classical adenocarcinoma type of prostate cancer. We present a case of an 83-year-old who had orchidectomy for treatment of metastatic prostate adenocarcinoma with normalization of prostate-specific antigen levels and subsequently developed recurrence with large cell neuroendocrine transformation.