Integrative analysis of single-cell and bulk RNA sequencing data for discovery of senescent TAMs prognostic characteristics in neuroblastoma

Senescent TAMs influence NB immunosuppression and progression. EIF5 is a key regulator of TAM senescence and a potential therapeutic target. Our risk model may guide clinical stratification and targeted interventions.

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Publication Details

Journal
BMC Cancer
Published
2026-01-06
DOI
https://doi.org/10.1186/s12885-025-15517-7
Primary Topic
Neuroblastoma Research and Treatments
Type
article
Field-Weighted Citation Impact
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article

Integrative analysis of single-cell and bulk RNA sequencing data for discovery of senescent TAMs prognostic characteristics in neuroblastoma

Qiyou Yin, Yiming Wang, Youyang Hu, Sitong Qiu et al.
BMC Cancer
Neuroblastoma Research and Treatments
article

Integrative analysis of single-cell and bulk RNA sequencing data for discovery of senescent TAMs prognostic characteristics in neuroblastoma

Qiyou Yin, Yiming Wang, Youyang Hu, Sitong Qiu, Hua Xian
article en

Abstract

Senescent TAMs influence NB immunosuppression and progression. EIF5 is a key regulator of TAM senescence and a potential therapeutic target. Our risk model may guide clinical stratification and targeted interventions.

BMC CancerVol. 26(1)
Nantong University (CN), Affiliated Hospital of Nantong University (CN)
Good health and well-being
Openalex Percentile: Top 95%
Neuroblastoma Research and Treatments
DOIOpen Access PDFOpenAlex
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Integrative analysis of single-cell and bulk RNA sequencing data for discovery of senescent TAMs prognostic characteristics in neuroblastoma — Qiyou Yin, Yiming Wang, et al. · BMC Cancer (2026) | TGRS Research Map | TGRS