Integrated bioinformatics and clinical validation reveals PRDX6 as a mitochondrial hub gene in systemic lupus erythematosus
This study suggested that PRDX6 might be a potential biomarker and exert protective effects by reducing oxidative stress in SLE. Key Points • IFI27 and PRDX6 serve as potential mitochondrial-related biomarkers in SLE. • PRDX6 is significantly downregulated in SLE. • PRDX6 is associated with SLEDAI score.
Authors
- Yan Xiao (ORCID: https://orcid.org/0000-0003-4242-6387)
- Yaxin Deng
- Jie Chen (ORCID: https://orcid.org/0000-0003-1379-2628)
- Yixin Jin
- Q W Dai
- Xingyu Liu
- Ting Peng
- Mei Zeng
Institutions
- North Sichuan Medical University (CN)
- Affiliated Hospital of North Sichuan Medical College (CN)
Publication Details
- Journal
- Clinical Rheumatology
- Published
- 2026-01-06
- DOI
- https://doi.org/10.1007/s10067-025-07860-8
- Primary Topic
- Redox biology and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 0.00