Pharmacological characterization and preclinical evaluation of 11h: a novel, brain-penetrant PDE4 inhibitor for neurological disorders

These findings suggest that 11h provides broad PDE4 inhibition with a favorable tolerability and pharmacokinetic profile relative to approved PDE4 inhibitors, supporting its further development as a therapeutic candidate for CNS disorders characterized by neuroinflammation.

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Publication Details

Journal
Frontiers in Pharmacology
Published
2026-01-08
DOI
https://doi.org/10.3389/fphar.2025.1720327
Primary Topic
Phosphodiesterase function and regulation
Type
article
Field-Weighted Citation Impact
0.00

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article

Pharmacological characterization and preclinical evaluation of 11h: a novel, brain-penetrant PDE4 inhibitor for neurological disorders

Atul Varadhachary, Jacob Lackovic, Sougata Dey, Sara Jane Ward et al.
Frontiers in Pharmacology
Phosphodiesterase function and regulation
article

Pharmacological characterization and preclinical evaluation of 11h: a novel, brain-penetrant PDE4 inhibitor for neurological disorders

Atul Varadhachary, Jacob Lackovic, Sougata Dey, Sara Jane Ward, Uksha Saini, David Tweedie, Nigel H. Greig, Dev Chatterjee, Nassim Beiranvand
article en

Abstract

These findings suggest that 11h provides broad PDE4 inhibition with a favorable tolerability and pharmacokinetic profile relative to approved PDE4 inhibitors, supporting its further development as a therapeutic candidate for CNS disorders characterized by neuroinflammation.

Frontiers in PharmacologyVol. 16
Texas Medical Center (US), Feminist Archive North (GB), South Texas Accelerated Research Therapeutics (US), National Institute on Aging (US), Io Therapeutics (United States) (US), Temple University (US)
Pharmaron
Good health and well-being
Openalex Percentile: Top 96%
Phosphodiesterase function and regulation
DOIOpen Access PDFOpenAlex
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Pharmacological characterization and preclinical evaluation of 11h: a novel, brain-penetrant PDE4 inhibitor for neurological disorders — Atul Varadhachary, Jacob Lackovic, et al. · Frontiers in Pharmacology (2026) | TGRS Research Map | TGRS