Does amitriptyline help for irritable bowel syndrome pain management?: An updated systematic review and meta-analysis

Amitriptyline significantly confers short-term improvements in abdominal pain and global IBS symptoms, but the certainty of evidence is limited by generally short follow-up, variable study quality, and incomplete reporting of safety and withdrawals. Longer, well-designed trials with standardized outcomes and systematic adverse-event monitoring are needed to clarify long-term effectiveness and tolerability.

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Publication Details

Journal
Medicine
Published
2026-01-02
DOI
https://doi.org/10.1097/md.0000000000046869
Primary Topic
Gastrointestinal motility and disorders
Type
article
Field-Weighted Citation Impact
0.00
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article

Does amitriptyline help for irritable bowel syndrome pain management?: An updated systematic review and meta-analysis

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Does amitriptyline help for irritable bowel syndrome pain management?: An updated systematic review and meta-analysis

Ghosoon Bafaraj, Raghad Alhajaji, Manal Z. Alfahmi, Alaa Mohammad Kadah Salim, Sara Bandar Badirah, Eatedal Mohammed Alshareef, Alshaymaa Khalid Mofareh, Sultan AlDhabei
article en

Abstract

Amitriptyline significantly confers short-term improvements in abdominal pain and global IBS symptoms, but the certainty of evidence is limited by generally short follow-up, variable study quality, and incomplete reporting of safety and withdrawals. Longer, well-designed trials with standardized outcomes and systematic adverse-event monitoring are needed to clarify long-term effectiveness and tolerability.

MedicineVol. 105(1)
Umm al-Qura University (SA), King Faisal Specialist Hospital & Research Centre (SA), King Saud Medical City (SA), King Saud University (SA), King Abdulaziz Medical City (SA), Ministry of Health (SA), King Abdullah Medical City (SA), Batterjee Medical College, Najran University (SA)
Good health and well-being
Openalex Percentile: Top 96%
Gastrointestinal motility and disorders
DOIOpen Access PDFOpenAlex
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