Breast composition and dose deposition to fat and fibroglandular tissues are associated with breast side effects after radiation therapy
Breast characterisation offers new insight into the link between dose and toxicity. Breast density and dose parameters from different substructures were associated with different breast toxicity. These findings further support the importance of dose homogeneity of breast RT planning.
Authors
- Maria Carmen De Santis (ORCID: https://orcid.org/0000-0003-3131-3969)
- Peter Hoskin (ORCID: https://orcid.org/0000-0001-8323-9567)
- Adam Webb (ORCID: https://orcid.org/0000-0002-6699-0479)
- Tim Rattay (ORCID: https://orcid.org/0000-0002-2824-4854)
- Jenny C. Chang (ORCID: https://orcid.org/0000-0002-0890-9302)
- Catharine ML. West
- Liv Veldeman (ORCID: https://orcid.org/0000-0002-0995-2687)
- D. Azria (ORCID: https://orcid.org/0000-0002-7533-2988)
- C. Talbot
- Barry S. Rosenstein (ORCID: https://orcid.org/0000-0002-3149-3237)
- Elena Sperk
- Zoe Lingard
- T. Rancati (ORCID: https://orcid.org/0000-0002-7849-603X)
- Sara Gutiérrez‐Enríquez (ORCID: https://orcid.org/0000-0002-1711-6101)
- Maarten Lambrecht (ORCID: https://orcid.org/0000-0002-8746-2691)
- Marianne Aznar (ORCID: https://orcid.org/0000-0001-6452-0310)
- Petra Seibold (ORCID: https://orcid.org/0000-0001-7360-6335)
- Tanwiwat Jaikuna (ORCID: https://orcid.org/0000-0002-3267-6166)
- Léa Kotzki
- Marcel van Herk
- Carmel Anandadas (ORCID: https://orcid.org/0000-0002-3651-5562)
- Victoria Reyes (ORCID: https://orcid.org/0000-0002-7934-1013)
- A. Vega
- Alejandro Seoane (ORCID: https://orcid.org/0000-0001-6856-3617)
- R.P. Symonds
- Dirk De Ruysscher (ORCID: https://orcid.org/0000-0002-1214-3557)
- Eliana Vasquez Osorio
- Fiona Wilson
Institutions
- University of Leicester (GB)
- Inserm (FR)
- Universität Hamburg (DE)
- German Cancer Research Center (DE)
- Université de Montpellier (FR)
- Heidelberg University (DE)
- Ghent University Hospital (BE)
- University Hospital Heidelberg (DE)
- University of Manchester (GB)
- Maastricht University (NL)
- Centre Hospitalier Universitaire de Nîmes (FR)
- University Medical Center Hamburg-Eppendorf (DE)
- Fundación Pública Galega de Medicina Xenómica (ES)
- University Cancer Center Hamburg (DE)
- Vall d'Hebron Hospital Universitari (ES)
- The Christie NHS Foundation Trust (GB)
- Institut de Recherche en Cancérologie de Montpellier (FR)
- University Medical Centre Mannheim (DE)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- Maastro Clinic (NL)
- Vall d'Hebron Institute of Oncology (ES)
- Icahn School of Medicine at Mount Sinai (US)
- KU Leuven (BE)
Publication Details
- Journal
- The Breast
- Published
- 2026-01-08
- DOI
- https://doi.org/10.1016/j.breast.2026.104694
- Citations
- 1
- Primary Topic
- Digital Radiography and Breast Imaging
- Type
- article
- Field-Weighted Citation Impact
- 36.44
Funders
- Fundación Cellex
- Deutsches Krebsforschungszentrum
- Centres de Recerca de Catalunya
- Cancer Research UK
- National Institute for Health and Care Research
- European Commission
- Bundesministerium für Bildung und Forschung
- Generalitat de Catalunya
- Manchester Biomedical Research Centre
- Engineering and Physical Sciences Research Council
- Agencia Estatal de Investigación
- NIHR Leicester Biomedical Research Centre