NCI9673 (Part B): ETCTN Randomized Phase II Study of Nivolumab With or Without Ipilimumab in Refractory, Metastatic Squamous Cell Carcinoma of the Anal Canal
The addition of ipilimumab to nivolumab did not statistically improve overall response rate, PFS, or OS but may harbor increased toxicity. Paired blood samples identified TIGIT expression on peripheral T cells as a compensatory change unique to dual PD-1 plus CTLA-4 blockade.
Authors
- Cathy Eng (ORCID: https://orcid.org/0000-0003-2335-0612)
- Christopher H. Lieu (ORCID: https://orcid.org/0000-0002-4852-4642)
- Howard S. Höchster (ORCID: https://orcid.org/0000-0002-9893-1529)
- Enrica Marmonti (ORCID: https://orcid.org/0000-0001-8745-490X)
- Olivia Aranha (ORCID: https://orcid.org/0000-0003-3405-5694)
- Cara Haymaker (ORCID: https://orcid.org/0000-0002-1317-9287)
- Kristen K. Ciombor (ORCID: https://orcid.org/0000-0002-5745-5909)
- Benjamin A. Weinberg (ORCID: https://orcid.org/0000-0002-0408-4817)
- Tony F. Shields
- Blasé N. Polite (ORCID: https://orcid.org/0000-0001-8743-8096)
- Lianchun Xiao (ORCID: https://orcid.org/0000-0003-0972-2766)
- Jennifer G. Whisenant (ORCID: https://orcid.org/0000-0002-3435-2464)
- S. Iqbal (ORCID: https://orcid.org/0000-0002-5010-5922)
- Syed Mohammad Ali Kazmi (ORCID: https://orcid.org/0000-0002-3367-367X)
- John C. Krauss (ORCID: https://orcid.org/0000-0002-5197-736X)
- Al B. Benson
- Sarbajit Mukherjee
- Van K. Morris
- Joshua K. Ochieng
- John Hays
Institutions
- Rutgers, The State University of New Jersey (US)
- Northwestern University (US)
- University of Southern California (US)
- Baptist Hospital of Miami (US)
- The University of Texas MD Anderson Cancer Center (US)
- Georgetown University (US)
- Vanderbilt University (US)
- Washington University in St. Louis (US)
- University of Michigan (US)
- University of Chicago (US)
- The Barbara Ann Karmanos Cancer Institute (US)
- Vanderbilt-Ingram Cancer Center
- University of Colorado Anschutz Medical Campus (US)
- The Ohio State University (US)
- The University of Texas Southwestern Medical Center (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2026-01-07
- DOI
- https://doi.org/10.1200/jco-25-00929
- Citations
- 1
- Primary Topic
- Colorectal and Anal Carcinomas
- Type
- article
- Field-Weighted Citation Impact
- 39.15