Effects of AD modifiable risk factors to tau‐PET tracer uptake and its association with cognitiion in early Braak stages
In this preliminary analysis, sleep disorders, hypertension, and high BMI were independently associated with tau-PET tracer uptake, with the effects varying according to amyloid-β pathology. These prevalent factors in the elderly also changed the association between tau-PET and cognition, underscoring the need for further studies to better understand their role in modulating this relationship.
Authors
- Val J. Lowe (ORCID: https://orcid.org/0000-0002-5612-1667)
- Dana Tudorascu (ORCID: https://orcid.org/0000-0003-4675-3692)
- Tharick Ali Pascoal (ORCID: https://orcid.org/0000-0001-9057-8014)
- Belén Pascual (ORCID: https://orcid.org/0000-0002-4467-7406)
- Joseph C. Masdeu (ORCID: https://orcid.org/0000-0001-9955-6954)
- Guilherme Bauer‐Negrini (ORCID: https://orcid.org/0000-0003-0956-557X)
- Emma Patrice Ruppert (ORCID: https://orcid.org/0000-0001-5877-5472)
- Matheus Scarpatto Rodrigues (ORCID: https://orcid.org/0000-0002-7794-6588)
- Bruna Bellaver (ORCID: https://orcid.org/0000-0002-2212-3373)
- Suzanne L. Baker (ORCID: https://orcid.org/0000-0003-0209-3127)
- Firoza Zubeida Lussier (ORCID: https://orcid.org/0000-0002-6877-4825)
- Markley Silva Oliveira (ORCID: https://orcid.org/0000-0002-0631-4065)
- David Soleimani‐Meigooni
- Pampa Saha (ORCID: https://orcid.org/0000-0002-4926-9081)
- Juan M. Fortea (ORCID: https://orcid.org/0000-0002-1340-638X)
- Hwamee Oh (ORCID: https://orcid.org/0000-0003-1156-5704)
- Pamela C.L. Ferreira
- Livia Amaral
- Guilherme Povala
- Carolina Soares
- Rayan Mroué
- Andreia Rocha
- Marina Scop Madeiros
- Brian A. Gordon
- Pedro Rosa‐Neto
Institutions
- Houston Methodist (US)
- Universidade Federal do Rio Grande do Sul (BR)
- Lawrence Berkeley National Laboratory (US)
- University of Pittsburgh (US)
- University of California, San Francisco (US)
- Washington University in St. Louis (US)
- Brown University (US)
- McGill University Health Centre (CA)
- Hospital de Sant Pau (ES)
- Mayo Clinic in Arizona (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_106398
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00